Non-Addictive Pain Therapeutics Development Grant
United States of America > Department of Health and Human Services > National Institutes of Health > National Institute of Neurological Disorders and Stroke
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The National Institutes of Health, through participating institutes including the National Institute of Neurological Disorders and Stroke, is seeking applications for the HEAL Initiative: Non-addictive Analgesic Therapeutics Development program. The opportunity supports milestone-driven preclinical optimization and development of small-molecule and biologic therapeutics for pain, with the ultimate goal of assembling and submitting an Investigational New Drug application and beginning Phase I clinical testing. Eligible projects must enter through a preparatory UG3 phase of no more than two years and may advance to an execution UH3 phase of no more than four years, for a total project period of no more than five years. Activities may include lead optimization, efficacy and ADMET testing, pharmacokinetic and pharmacodynamic studies, biomarker development, formulation and stability work, manufacturing, toxicology, IND preparation, and Phase I clinical studies. Applications must include activities for both phases, annual go/no-go milestones, a target product profile, annual budgets, and an Intellectual Property Strategy attachment. The NIH anticipates approximately $11,000,000 in total funding for three awards in fiscal year 2027.
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| Title | Date Posted |
|---|---|
| rfp06162615 | Jun 16, 2026 03:00 PM |
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