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Protein ENGineering (PENG) Program

DARPA is soliciting proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins, with the goal of transitioning proteome engineering into a universal, software-defined discipline.

United States of America > DEPT OF DEFENSE > DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) > DEF ADVANCED RESEARCH PROJECTS AGCY

General
Open
DARPA-PS-26-129
Oct 19, 2026 08:00 PM
Aug 21, 2026 05:27 PM
1 year 6 months base + options: 6 months, 1 year 6 months
Request for Proposal (RFP)
Federal
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Original Solicitation Links
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DARPA-PS-26-129

]

protein engineering (peng)

Contact
BAA Coordinator
peng@darpa.mil
675 North Randolph Street, Arlington, VA, USA
Submission Instructions
Online
https://www.darpa.mil/work-with-us/contract-management/proposer-general-terms
Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Classification Codes
NAICS541714Research and Development in Biotechnology (except Nanobiotechnology)
PSCAC12DEFENSE AIRCRAFT - APPLIED RESEARCH/EXPLORATORY DEVELOPMENT
Smart Codes
protein editing platformprogrammable protein targetingmultiplexed protein engineering
Specifications
Service Only
Timeline
Aug 7, 2026-Published Date
Aug 10, 2026-Proposers Day
Aug 17, 2026-Question Submittal Closed
Aug 24, 2026-Proposal Abstract Due Date
Oct 19, 2026-Tentative Proposal Due Date
Nov 18, 2026-Inactive Date
Location
675 North Randolph Street, Arlington, VA, USA
View on Google Maps
Documents
TitleDate Posted
Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docxAug 07, 2026 12:00 PM
Attachment_A_Abstract_Summary_Side.pptxAug 07, 2026 12:00 PM
Attachment_G_Model_Other_Transaction_for_Prototype.docxAug 07, 2026 12:00 PM
Attachment_C_Proposal_Summary_Slide_Template.pptxAug 07, 2026 12:00 PM
Attachment_B_Abstract_Instructions_and_Template.docxAug 07, 2026 12:00 PM
Attachment_H_Task_Description_Document__TDD_.docxAug 07, 2026 12:00 PM
Attachment_I_Schedule_of_Milestones_and_Payments.xlsxAug 07, 2026 12:00 PM
DARPA-PS-26-129.pdfAug 07, 2026 12:00 PM
Attachment_D_Proposal_Instructions_and_Volume_I_Template_Technical_and_Management.docxAug 07, 2026 12:00 PM
DARPA-PS-26-129-Amendment-01.pdfAug 21, 2026 12:00 PM
Attachment_F_DARPA_Cost_Proposal_Spreadsheet.xlsxAug 07, 2026 12:00 PM
PENG_Amendment_1_Summary_of_Changes.docxAug 21, 2026 12:00 PM
Attachment_D_Proposal_Inst_and_Vol_I_Template_Tech_and_Management_Amendment_1.docxAug 21, 2026 12:00 PM
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