Quantum-Enabled Biomedical Imaging Research

The Advanced Research Projects Agency for Health is seeking innovative research proposals for quantum-enabled biomedical imaging using entangled 511 keV photons, quantum-aware detectors, and AI-driven reconstruction and data fusion under an 18-month, two-phase program.

United States of America > HEALTH AND HUMAN SERVICES, DEPARTMENT OF > NATIONAL INSTITUTES OF HEALTH > ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)


General
Open (active)
ARPA-H-SOL-26-162
Dec 16, 2026 04:59 AM
Sep 16, 2026 06:49 PM
9 months base + 1 × 9 months option
Request for Proposal (RFP)
Federal
Ask AI about this solicitation
Contact
unique@arpa-h.gov
1301 K Street NW, Washington, DC, USA
Submission Instructions

All of the following are required.

Step 1

Online
Solution Summary

Step 2

Online
Full Proposal
Description

The Advanced Research Projects Agency for Health is soliciting innovative research proposals for the UNifying Imaging with QUantum Entanglement program. Proposers must address both technical areas: development of physical systems for generating and measuring quantum-derived imaging contrast using entangled 511 keV photon pairs, positronium-sensitive interactions, and decoherence-aware imaging architectures; and development of quantum-aware artificial intelligence for reconstruction, multimodal data fusion, uncertainty quantification, and real-time interpretation of anatomical, functional, molecular, and quantum-derived information. The program is structured as an 18-month, two-phase effort, with continuation into the second phase determined by program progress. Expected work includes controlled phantom and benchtop demonstrations, quantum-derived contrast measurements, ghost-image reconstruction, multidimensional imaging outputs, and biological-state interpretation. Multiple Other Transaction Agreements are anticipated. Solution summaries and full proposals must follow the specified templates and formatting requirements, with full proposals comprising technical and management, cost, and administrative/policy volumes submitted through the designated online portal.

Classification Codes
NAICS541714Research and Development in Biotechnology (except Nanobiotechnology)
PSCAN13BIOMEDICAL - ADVANCED DEVELOPMENT
Smart Codes
quantum imaging researchbiomedical imaging airesearch and development
Specifications
Service Only
Timeline
Sep 16, 2026-Posting Date
Oct 10, 2026 05:00 PM-Questions and Answers Due
Oct 15, 2026 12:30 PM-Proposers' Day (optional)
In-person and virtual event; the site is to be determined. The video link is provided as https://arpa-h.gov/explore-funding/programs/unique.
Oct 15, 2026 07:00 PM-Lightning Talk / Sidebar Session (optional)
The solicitation lists a 3:00–5:00 PM session but does not provide a physical address or separate joining information.
Oct 31, 2026 03:59 AM-Solution Summaries Due
Dec 16, 2026 04:59 AM-Full Proposals Due
Requirements
Scored
Documents
TitleDate Posted
UNIQUE-ISO-ARPA-H-SOL-26-162.pdfSep 16, 2026 12:00 PM
UNIQUE ISO Attachments.zipSep 16, 2026 12:00 PM
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