Development of Research Models and Materials for Human Health and Disease Studies

The Department of Health and Human Services is seeking grant applications for the development of research models and related materials for studying human health and diseases, excluding clinical trials.

General
Open (posted)
RFA-OD-25-010
Sep 28, 2028 12:00 PM
Dec 05, 2025 12:00 PM
$50,000.00
Grant
Federal
Public Trust
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Contact
Office of Research Infrastructure Programs (ORIP)
oripdcm@mail.nih.gov
Description

The Office of Research Infrastructure Programs (ORIP) is soliciting grant applications for the development, characterization, or improvement of research models for human health and diseases. This includes the development of biology-based new approach methodologies (NAMs) applicable to human health and diseases, and the improvement of access to information generated from the use of disease models. The developed models and related biological materials must have broad applicability to the scientific interests of at least two NIH Institutes or Centers (ICs) and address diseases and processes impacting multiple organ systems. Applications should highlight the need for and potential impact of the proposed resources on the broader research community across various scientific disciplines supported by multiple NIH ICs. Projects focused solely on a specific disease or a narrow research area, or those with limited impact on the overall NIH research community, will not be considered. Foreign organizations are not eligible to apply, and foreign components of U.S. organizations are also prohibited. This opportunity is a discretionary grant with an estimated total program funding of $5,000,000 and an expected number of 6 awards. The Assistance Listing number is 93.351, under Research Infrastructure Programs.

Classification Codes
NAICS541715Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
PSCAN11BIOMEDICAL - BASIC RESEARCH
Smart Codes
disease research modelshealth research materialsnew approach methodologiesbiological materials developmentclinical trial researchnih research grantshealth research infrastructuredisease research materialsbiomedical research modelshealth research development
Timeline
Dec 5, 2025-Post Date
Sep 28, 2028-Close Date
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