The Genesis Mission: Transforming Science and Energy with AI

The Department of Energy's Office of Science is seeking applications for interdisciplinary teams to advance scientific discovery and R&D workflows using novel artificial intelligence models and frameworks.

General
Open (posted)
DE-FOA-0003612
Dec 17, 2026 12:00 PM
Mar 17, 2026 12:00 PM
$750,000.00
Request for Proposal (RFP)
Federal
Ask AI about this solicitation
Original Solicitation Links
Contact
genesismissionnofo@science.doe.gov
Description

The Department of Energy (DOE) Office of Science, along with several other DOE offices, is soliciting applications for the Genesis Mission National Science and Technology Challenges. This initiative aims to accelerate scientific discovery and research and development (R&D) workflows by leveraging novel artificial intelligence (AI) models and frameworks. The goal is to achieve an AI advantage that will advance the DOE's mission in energy, environmental, and nuclear challenges, ultimately ensuring America's security and prosperity. Teams are encouraged to utilize the extensive scientific and data resources available through the DOE, National Laboratories, U.S. industry, and academia. The resulting AI models and workflows may be integrated into the American Science Cloud. This Request for Application (RFA) seeks applications for both Phase I (small teams) and Phase II (large teams) projects. The focus areas cover a broad spectrum of scientific and technological domains, including advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy. The program structure includes a phased approach, with Phase I focusing on demonstrating AI advantage and Phase II on pursuing promising directions identified in Phase I, with a significantly larger scope and budget.

Classification Codes
NAICS541715Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
PSCAZ12OTHER RESEARCH AND DEVELOPMENT - APPLIED RESEARCH/EXPLORATORY DEVELOPMENT
Smart Codes
artificial intelligence researchenergy innovationscientific discovery acceleration
Timeline
Mar 17, 2026-Post Date
Dec 17, 2026-Close Date
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